Researchers from VHIR and ICMAB-CSIC obtain first images of human endothelial stem cells at ALBA Synchrotron
Dr. Anna Rosell from the Neurovascular Research group at VHIR, Dr. Anna Roig from the Group of Nanoparticles and Nanocomposites at the Institut de Ciència de Materials de Barcelona (ICMAB-CSIC) and Dr. Eva Pereiro, responsible of the ALBA synchrotron light source, have obtained the first images of human endothelial stem cells by Transmission Soft X-ray Microscopy at ALBA Synchrotron in Cerdanyola del Vallès.
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Following lengthy preparations researchers have obtained the first cryo X-ray tomographies of human endothelial progenitor cells. With this experiment, after imaging reconstruction, they expect to obtain tomographic data sets of 50-60 nm resolution that will allow gathering 3D views of the whole cells allowing a comparative study (size and morphology) of the iron-loaded cells with the pristine cells, as well as between the different EPC subtypes. In addition the researchers aim to determine the spatial bulk distribution of the endosomes/lysosomes containing nanoparticles inside the cells.
The project is currently funded by the Instituto Carlos III-FIS and Ministerio de Economia y Competitividad.
According to the World Health Organization, 15 million persons suffer a stroke worldwide each year. The incidence of this disease in Europe is approximately 200-250 cases every 100,000 inhabitants. It is estimated that at present less than 5% of those patients receive treatment.
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